Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest
نویسندگان
چکیده
منابع مشابه
Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest.
Streptococcus pneumoniae produces pneumolysin toxin as a key virulence factor against host cells. Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host membranes and mediates pneumococcal disease pathogenesis by modulating inflammatory responses. Here, we show that pneumolysin, which is released during bacterial lysis, induces DNA double strand breaks (DSBs...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep22972